Description
PROMOGRAN Matrix Wound Dressing
3M Health Care is now Solventum. The same products you know and trust, now under a new brand.
PROMOGRAN™ Matrix is a wound dressing designed to create a moist healing environment that is conducive to rapid wound healing. To do this, the dressing starts with a freeze-dried composite to deliver a protease modulating matrix made up of collagen (55%) and oxidized regenerated cellulose (ORC) (45%), an organic compound. Together, these components guide the wound through healing, encouraging epithelialization and tissue formulation across a range of injuries.
What is ORC?
Cellulose is a major component of all plants. Once oxidized, ORC (Oxidized Regenerated Cellulose) is completely bioresorbable, and readily degrades through fluid absorption and subsequent gelling.
Studies show ORC:
• Has hemostatic properties
• Stimulated cell migration and growth
• Has bactericidal properties
• Reduced protease activity levels, specifically elastase and MMPs
• Scavenged free radicals and bound excess metal ions
Optimum Wound Environment
PROMOGRAN™ Matrix transforms into a soft, conformable, biodegradable gel. This allows contact with all areas of the wound. When covered with a semi-occlusive or non-occlusive dressing, it maintains an optimal wound healing environment. This environment is conducive to granulation tissue formation, epithelization and rapid wound healing.
Indications and Applications
PROMOGRAN™ Matrix is intended for the management of exuding wounds, including:
- Diabetic ulcers
- Venous ulcers
- Pressure ulcers
- Ulcers caused by mixed vascular etiologies
- Full-thickness and partial thickness wounds
- Donor sites and other bleeding surface wounds
- Abrasions
- Traumatic wounds healing by secondary intention
- Dehisced surgical wounds
- PROMOGRAN™ Matrix can be used under compression therapy with healthcare professional supervision
PROMOGRAN™ Matrix Wound Dressing is not indicated for wounds with active vasculitis, third-degree burns, or patients with known sensitivity to ORC or collagen.
PROMOGRAN PRISMA™ Matrix may be used when visible signs of infection are present in the wound area only when proper medical treatment addresses the underlying cause. PROMOGRAN PRISMA™ Matrix is not intended to be a substitute for appropriate treatment of infection.
How to Use PROMOGRAN™ Matrix
For optimal effect, apply PROMOGRAN™ Matrix directly to the whole wound bed.
- Prepare the wound bed per your standard wound care protocol and debride when necessary. The wound bed should be clear of any visual signs of infection.
- For a wound with low or no exudate apply PROMOGRAN™ Matrix and hydrate with saline solution. This will initiate the transformation of the PROMOGRAN™ Matrix into a gel.
- After hydration, through exposure to wound exudate or saline, the PROMOGRAN™ Matrix gel will intimately come into contact with the wound surface.
- The biodegradable PROMOGRAN™ Matrix gel is naturally absorbed into the body over time.
- In order to maintain a moist wound healing environment, PROMOGRAN™ Matrix must be covered with a semi-occlusive or non-occlusive secondary dressing and fixed to the skin with a non-irritating tape.
- After initial application, reapply PROMOGRAN™ Matrix to the wound up to every 72 hours depending upon the amount of exudate. It is not necessary to remove any residual PROMOGRAN™ Matrix during dressing changes.
Downloadable Resources

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Collagen and ORC
Related Products
Product Item Number
PG004, PG019