Endoform™ Antimicrobial Restorative Bioscaffold and Endoform™ Natural Restorative Bioscaffold are unique extracellular matrix (ECM) products for the management of acute and chronic wounds. Endoform™ products supports all phases of wound healing and are appropriate for use early in wound management to restore protease balance and advance healing to the proliferative phase. ¹

Endoform™ Antimicrobial Restorative Bioscaffold

Endoform™ Natural Restorative Bioscaffold

Endoform™ products:

• Provide a natural porous ECM bioscaffold for rapid cell infiltration ²

• Contains more than 150 ECM proteins known to be important in wound healing ³

• Contain residual vascular channels to support the establishment of new vasculature ⁴

• Can indicate the presence or absence of proteases and help restore protease balance and guide re-application ⁵

• Can be used by any wound care provider from day 1 ¹

Endoform™ Antimicrobial Restorative Bioscaffold contains 0.3% ionic silver, appropriate for use in early acute and chronic wound management where there is an elevated risk of infection.

• Provides broad spectrum antimicrobial activity for up to 7 days* ⁶

• Prevents biofilm formation ⁶

• Is non-cytotoxic to dermal cells ⁶

*Endoform™ Antimicrobial contains 0.3% ionic silver to protect the dressing from microbial colonization

How It Works

Endoform™ Antimicrobial and Endoform™ Natural Restorative Bioscaffold products work in all phases of healing to stabilize, correct, build and organize tissue.

Endoform™ products are made from AROA ECM™ technology and contain more than 150 extracellular matrix (ECM) proteins that enable it to interact with patient’s cells throughout all phases of healing.(1, 2) Endoform™ products are 85% collagen and 15% important secondary molecules, including structural and adhesion proteins, and glycosaminoglycans (GAGs).(1) Endoform™ products only contain components found in tissue extracellular matrix.

During the inflammatory phase, chronic wounds are characterized by elevated wound proteases that limit healing by digesting important dermal proteins(3) Endoform™ products can help indicate the presence or absence of proteases and restores protease balance.(4, 5) If Endoform™ products are not visible in the wound bed at the time of reapplication, this can indicate elevated wound protease activity. However, if Endoform™ is visible, this can indicate that protease balance has been restored.

Endoform™ products also contain residual vascular channels that facilitate the rapid establishment of a dense capillary network by supporting migrating endothelial cells to establish new vasculature and a robust blood supply to help build new tissue.(6) This process is termed angioconduction.


Endoform™ Antimicrobial Restorative Bioscaffold and Endoform™ Natural Restorative Bioscaffold products are indicated for the management of acute and chronic wounds including:

• Partial and full thickness wounds

• Pressure ulcers

• Venous ulcers

• Diabetic ulcers

• Chronic vascular ulcers

• Tunneled/undermined wounds

• Surgical wounds (donor sites, grafts, post Moh’s surgery, post laser surgery, podiatric, wound dehiscence)

• Traumatic wounds (abrasions, lacerations, second-degree burns, and skin tears)

• Draining wounds


1. G. A. Bohn, G. S. Schultz, B. A. Liden, M. N. Desvigne, E. J. Lullove, I. Zilberman, M. B. Regan, M. Ostler, K. Edwards, G. M. Arvanitis and J. F. Hartman: Proactive and Early Aggressive Wound Management: A Shift in Strategy Developed by a Consensus Panel Examining the Current Science, Prevention, and Management of Acute and Chronic Wounds. Wounds, 29(11), S37-S42 (2017).

2. S. Lun, S. M. Irvine, K. D. Johnson, N. J. Fisher, E. W. Floden, L. Negron, S. G. Dempsey, R. J. McLaughlin, M. Vasudevamurthy, B. R. Ward and B. C. May: A functional extracellular matrix biomaterial derived from ovine forestomach. Biomaterials, 31(16), 4517-29 (2010) doi:10.1016/j.biomaterials.2010.02.025.

3. S. G. Dempsey, C. H. Miller, R. C. Hill, K. C. Hansen and B. C. H. May: Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix. J Proteome Res, 18(4), 1657-1668 (2019) doi:10.1021/acs.jproteome.8b00908.

4. Smith MJ, Dempsey SG, Veale RW, et al. Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair. Journal of Biomaterials Applications. 2022;36(6):996-1010. doi:10.1177/08853282211045770.

5. G. A. Bohn: Endoform: A Simple Tool to Assess Wound Proteases. Wound Management and Prevention, 65(3), 18-20 (2019).

6. T. Karnik, S. G. Dempsey, M. J. Jerram, A. Nagarajan, R. Rajam, B. C. H. May and C. H. Miller: Ionic silver functionalized ovine forestomach matrix – a non-cytotoxic antimicrobial biomaterial for tissue regeneration applications. Biomater Res, 23, 6 (2019) doi:10.1186/s40824-019-0155-0